Bioavailability of dexlansoprazole delayed-release capsule granules when administered via nasogastric tube or orally via syringe.

ABSTRACT:

Objective

To assess the effect of route of administration on the bioavailability of dexlansoprazole 60 mg delayed-release capsule granules.

Methods

One open-label, Phase I, single-dose, 3-period crossover study was conducted in healthy adults. The bioavailability of Dexilant^® (dexlansoprazole) after dexlansoprazole capsule granules were mixed with water and administered via 16 French nasogastric tube or orally via syringe was compared to administration of the intact capsule in the fasted state, swallowed with water. Blood samples were collected before and after dosing to determine dexlansoprazole pharmacokinetic parameter estimates and plasma concentrations.

Results

Similar values for area under the plasma concentration-time curve and observed maximum plasm

SUBMITTER: Kukulka M 

PROVIDER: S-EPMC6177519 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature