The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis.

ABSTRACT:

Background and purpose

The polyphenol resveratrol (RSV) exists in high quantities in certain foods (e.g. grapes and nuts). However, the capacity of RSV to confer physiological health benefits and a biological mechanism through which this might occur remains unclear.

Experimental approach

Aged, RSV-treated (300 mg·kg^-1 ·day^-1 ) and genetically modified [endothelial NOS (eNOS^-/- )] female mice were assessed using histomorphometric and μCT analysis. Alongside in vivo analysis, molecular siRNA knockdown and pharmacological manipulation of eNOS, BMP2 and sirtuin 1 (SIRT1) and functional cellular assays in an osteoblast cell line panel, explored the mechanism through which RSV might impact overall bone volume.

Key results

RSV promoted osteob

SUBMITTER: Zhao M 

PROVIDER: S-EPMC6177622 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature