Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.

ABSTRACT: Bruton's tyrosine kinase (Btk) is a crucial regulator of B cell signaling and is a therapeutic target for lymphoma and autoimmune disease. BTK-deficient patients suffer from humoral immunodeficiency, as their B cells fail to progress beyond the bone marrow. However, the role of Btk in fully developed, mature peripheral B cells is not well understood. Analysis using BTK inhibitors is complicated by suboptimal inhibition, off-target effects, or failure to eliminate BTK's adaptor function. Therefore a Btk^flox/Cre-ER^T2 mouse model was developed and used to excise Btk after B cell populations were established. Mice lacking Btk from birth are known to have reduced follicular (FO) compartments, with expanded transitional populations, suggesting a

SUBMITTER: Nyhoff LE 

PROVIDER: S-EPMC6177684 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature