The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.

ABSTRACT: INTRODUCTION:An animal model of late-onset Alzheimer's disease is needed to research what causes degeneration in the absence of dominant genetic insults and why the association cortex is particularly vulnerable to degeneration. METHODS:We studied the progression of tau and amyloid cortical pathology in the aging rhesus macaque using immunoelectron microscopy and biochemical assays. RESULTS:Aging macaques exhibited the same qualitative pattern and sequence of tau and amyloid cortical pathology as humans, reaching Braak stage III/IV. Pathology began in the young-adult entorhinal cortex with protein kinase A-phosphorylation of tau, progressing to fibrillation with paired helical filaments and mature tangles in oldest animals. Tau pathology in the dorsolateral prefrontal cortex paralleled but

SUBMITTER: Paspalas CD 

PROVIDER: S-EPMC6178089 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature