Inflammatory projections after focal brain injury trigger neuronal network disruption: An ¹⁸F-DPA714 PET study in mice.

ABSTRACT: Due to the heterogeneous pathology of traumatic brain injury (TBI), the exact mechanism of how initial brain damage leads to chronic inflammation and its effects on the whole brain remain unclear. Here, we report on long-term neuroinflammation, remote from the initial injury site, even after subsiding of the original inflammatory response, in a focal TBI mouse model. The use of translocator protein-positron emission tomography in conjunction with specialised magnetic resonance imaging modalities enabled us to visualize "previously undetected areas" of spreading inflammation after focal cortical injury. These clinically available modalities further revealed the pathophysiology of thalamic neuronal degeneration occurring as resident microglia sense damage to corticothalamic neuronal tracts a

SUBMITTER: Hosomi S 

PROVIDER: S-EPMC6178196 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature