Exercise intervention alters HDL subclass distribution and function in obese women.

ABSTRACT:

Background

Obesity is associated with a change in high-density lipoprotein (HDL) function and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to explore the effect of an exercise training stimulus on HDL functionality and subclass in obese women.

Methods

Thirty-two obese black South African women were randomly assigned to exercise (combined aerobic and resistance exercise) or control (no exercise) conditions for 12-weeks. Pre- and post-testing included venous blood sampling for analysis of lipid profile and HDL functionality, by measuring cellular cholesterol efflux capacity, reduction in endothelial vascular cell adhesion molecule (VCAM) expression (anti-inflammatory function), paraoxonase (PON) (antioxidative function) and platelet activ

SUBMITTER: Woudberg NJ 

PROVIDER: S-EPMC6178267 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature