Highly selective transition-metal-free transamidation of amides and amidation of esters at room temperature.

ABSTRACT: Amide chemistry has an essential role in the synthesis of high value molecules, such as pharmaceuticals, natural products, and fine chemicals. Over the past years, several examples of transamidation reactions have been reported. In general, transition-metal-based catalysts or harsh conditions are employed for these transformations due to unfavorable kinetics and thermodynamics of the process. Herein, we report a significant advance in this area and present the general method for transition-metal-free transamidation of amides and amidation of esters by highly selective acyl cleavage with non-nucleophilic amines at room temperature. In contrast to metal-catalyzed protocols, the method is operationally-simple, environmentally-friendly, and operates under exceedingly mild conditions. The pract

SUBMITTER: Li G 

PROVIDER: S-EPMC6178361 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature