Carrier Cells for Delivery of Oncolytic Measles Virus into Tumors: Determinants of Efficient Loading.

ABSTRACT: Oncolytic measles virus (OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies (NAbs) against the hemagglutinin (H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge, specific types of cells have been used as carriers for OMV. Differential loading strategies appear to result in different therapeutic outcomes; despite this, only few studies have reported practical ex vivo loading strategies required for effective treatment. To this end, we systematically evaluated the antitumor efficacy of OMV using different loading strategies; this involved varying the in vitro loading duration and loading dose of OMV. We found that improved oncolysis of carrier cells was achieved b

SUBMITTER: Xu C 

PROVIDER: S-EPMC6178551 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature