Adrenaline enhances in vitro platelet activation and aggregation in blood samples from ticagrelor-treated patients.

ABSTRACT:

Background

Temporarily improved platelet reactivity may reduce the bleeding in patients on antiplatelet therapy who have ongoing bleeding or who are in need of acute surgery. Adrenaline can bind to adrenergic α_2A-receptors on platelets and potentially enhance platelet reactivity.

Objective

To assess if adrenaline can improve adenosine diphosphate (ADP)-induced platelet aggregation and activation in blood samples from patients on dual antiplatelet therapy with acetylsalicylic acid (ASA) and the ADP-receptor antagonist ticagrelor.

Methods

Blood samples were collected from a total of forty acute coronary syndrome patients on dual antiplatelet therapy with ASA and ticagrelor. ADP-induced platelet aggregation (by impedance aggregometry) and activation (by flow c

SUBMITTER: Singh S 

PROVIDER: S-EPMC6178615 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature