A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes.

ABSTRACT: Cutaneous squamous cell carcinoma (SCC) is the second-most-common cancer in Australia. The majority of SCCs progress from premalignant actinic keratosis (AK) lesions that form on chronically sun-exposed skin. The role of skin microbiota in this progression is not well understood; therefore, we performed a longitudinal microbiome analysis of AKs and SCCs using a cohort of 13 SCC-prone immunocompetent men. The majority of variability in microbial profiles was attributable to subject, followed by time and lesion type. Propionibacterium and Malassezia organisms were relatively more abundant in nonlesional photodamaged skin than in AKs and SCCs. Staphylococcus was most commonly associated with lesional skin, in particular, sequences most closely related to Staphylococcus

SUBMITTER: Wood DLA 

PROVIDER: S-EPMC6178618 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature