Clinical Scales Predict Significant Videofluoroscopic Dysphagia in Machado Joseph Disease Patients.

ABSTRACT:

Background

Although aspiration is one of the main causes of death in SCA, such as SCA3/Machado Joseph disease (SCA3/MJD), clinical studies on dysphagia are lacking for these diseases. The aims of this study were to characterize dysphagia in SCA3/MJD through videofluoroscopy (VF) of swallowing, correlate VF with disease severity criteria and weight loss, and determine the clinical criteria cutoffs for performing VF in the clinical routine, in order to detect aspiration.

Methods

A cross-sectional study on 34 SCA3/MJD patients was performed. Clinical and molecular data, as well as body mass index (BMI), were obtained. Neurological scales, such as the Scale for the Assessment and Rating of Ataxia (SARA), and the Swallowing Quality of Life (SWAL-QOL) questionnaire were applied. T

SUBMITTER: Russo AD 

PROVIDER: S-EPMC6178754 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature