The Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease: Is There an Influence of Age?

ABSTRACT:

Background

DBS is commonly used to treat Parkinson's disease (PD). DBS is not considered to cause major cognitive side effects, but some research groups have reported that it can cause decreased verbal fluency. The influence of age on DBS cognitive outcome is unclear. We investigated the possible influence of patients' age, level of education, disease duration, disease progression, depression, and levodopa equivalent dose (LED) on verbal fluency performance in patients with PD who underwent DBS of the subthalamic nucleus (STN-DBS). In this article, we investigated the influence of demographic and clinical parameters, especially age, on cognitive performance post-DBS in PD patients.

Methods

Forty-three patients with PD and without major psychiatric illness (according to Diagn

SUBMITTER: Cozac VV 

PROVIDER: S-EPMC6178760 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature