Menstrual Cycle Characteristics in Adolescence and Early Adulthood Are Associated With Risk of Early Natural Menopause.

ABSTRACT:

Context

Early natural menopause (i.e., before age 45 years) is associated with increased risk of adverse outcomes. Associations of earlier menopause with younger age at menarche and short and/or regular cycle length are suggested, but study findings are inconsistent and few address early menopause risk.

Objective

To evaluate the relationship between menstrual cycle characteristics in early life with incident early natural menopause.

Design

The prospective Nurses' Health Study 2 (1989 to 2011).

Setting and participants

Women ages 25 to 42 years and premenopausal in 1989 (N = 108,811).

Main outcome measure(s)

Risk of early natural menopause not due to surgery, radiation, or chemotherapy (n = 2794) was evaluated with Cox proportional hazards models. Anti-Mü

SUBMITTER: Whitcomb BW 

PROVIDER: S-EPMC6179161 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature