Newborn Screening for Primary Congenital Hypothyroidism: Estimating Test Performance at Different TSH Thresholds.

ABSTRACT: Context:Active surveillance of primary congenital hypothyroidism (CH) in a multiethnic population with established newborn bloodspot screening. Objective:To estimate performance of newborn screening for CH at different test thresholds and calculate incidence of primary CH. Design:Prospective surveillance from June 2011 to June 2012 with 3-year follow-up of outcomes. Relative likelihood ratios (rLRs) estimated to compare bloodspot TSH test thresholds of 6 mU/L and 8 mU/L, with the nationally recommended standard of 10 mU/L for a presumptive positive result. Setting:UK National Health Service. Patients:Clinician notification of children aged <5 years investigated following clinical presentation or presumptive positive screening result. Main Outcome Measure(s):Permanent primary CH status dete

SUBMITTER: Knowles RL 

PROVIDER: S-EPMC6179177 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature