Paradigm Shifts in Nocturnal Glucose Control in Type 2 Diabetes.

ABSTRACT:

Context

A better understanding of nocturnal regulation of glucose homeostasis will provide the framework for designing rational therapeutic strategies to improve the management of overnight glucose in patients with type 2 diabetes (T2D).

Objective

To establish the nocturnal pattern and regulation of glucose production (EGP) in humans and to determine whether the pattern is dysregulated in people with T2D.

Design

Subjects were infused with [3-3H] glucose overnight. Arterial blood samples were drawn for hormones and analytes to estimate EGP throughout the night. Deuterium-labeled water was provided to measure gluconeogenesis (GNG) using the hexamethylenetetramine method of Landau.

Setting

Mayo Clinic Clinical Research Trials Unit, Rochester, MN, USA.

Participa

SUBMITTER: Basu A 

PROVIDER: S-EPMC6179178 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature