Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.

ABSTRACT:

Background

Chagas disease is a neglected tropical disease. About 6 to 8 million people are chronically infected and 10% to 15% develop irreversible gastrointestinal disorders, including megaesophagus. Treatment focuses on improving symptoms, and isosorbide and nifedipine may be used for this purpose.

Methodology

We conducted a systematic review to evaluate the effectiveness of pharmacological treatment for Chagas' megaesophagus. We searched MEDLINE, Embase and LILACS databases up to January 2018. We included both observational studies and RCTs evaluating the effects of isosorbide or nifedipine in adult patients with Chagas' megaesophagus. Two reviewers screened titles and abstracts, selected eligible studies and extracted data. We assessed the risk of bias using NIH 'Quality

SUBMITTER: Borges Migliavaca C 

PROVIDER: S-EPMC6179300 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature