Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.

ABSTRACT: New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, some studies have suggested that hundreds of new neurons are added to the adult dentate gyrus every day, whereas other studies find many fewer putative new neurons. Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development. We also find that the number of proliferating progenitors and young neurons in the dentate gyrus declines shar

SUBMITTER: Sorrells SF 

PROVIDER: S-EPMC6179355 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature