Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia.

ABSTRACT: Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. C

SUBMITTER: Teipel S 

PROVIDER: S-EPMC6179371 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature