Predicting the tissue depth for remote triggering of drug delivery systems.

ABSTRACT: Externally triggerable drug delivery systems have promising potential in providing flexible control of the timing, duration, and intensity of treatment according to patient's needs, while reducing side effects and increasing therapeutic efficacy. However, a limitation to translating such systems into clinical practice is the difficulty to predict the tissue depth at which such systems could be safely used in vivo (e.g. activatable at the target site with a clinically-safe energy dosage). An effective method is needed to evaluate the clinical potential of externally triggerable drug delivery systems. Here we have a method and approach to predicting the tissue depth at which a drug delivery system can be safely triggered in vivo by an external energy source. We used in vitro and ex vivo expe

SUBMITTER: Rwei AY 

PROVIDER: S-EPMC6179450 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature