A novel cross-correlation methodology for assessing biophysical responses associated with pain.

ABSTRACT:

Purpose

The purpose of this work was to noninvasively detect and quantify microvascular blood flow changes in response to externally applied pain in humans. The responsiveness of the microvasculature to pain stimulation might serve as an objective biomarker in diseases associated with altered pain perception and dysregulated vascular functions. The availability of such a biomarker may be useful as a tool for predicting outcome and response to treatments, particularly in diseases like sickle cell anemia where clinical manifestations are directly linked to microvascular perfusion. We, therefore, developed a method to distinguish the blood flow response due to the test stimulus from the blood flow measurement that also includes concurrent flow changes from unknown origins.

Subjects

SUBMITTER: Sunwoo J 

PROVIDER: S-EPMC6179586 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature