The mediating effects of gestational diabetes on fetal growth and adiposity in women who are overweight and obese: secondary analysis of the LIMIT randomised trial.

ABSTRACT:

Objective

To describe the mediating effect of maternal gestational diabetes on fetal biometry and adiposity measures among overweight or obese pregnant women.

Design

Secondary analysis of the LIMIT randomised trial.

Setting

Public hospitals, metropolitan Adelaide, South Australia.

Population

Pregnant women with body mass index (BMI) ≥25 kg/m² and singleton gestation.

Methods

Fetal ultrasound measures at 36 weeks of gestation and baseline BMI from women randomised to the LIMIT trial Standard Care group (n = 912 women) were used to conduct causal mediation analyses using regression-based methods.

Main outcomes measures

Ultrasound measures of fetal biometry and adiposity at 36 weeks of gestation.

Results

Increased maternal BMI was a

SUBMITTER: Poprzeczny AJ 

PROVIDER: S-EPMC6179915 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature