Environmental pleiotropy and demographic history direct adaptation under antibiotic selection.

ABSTRACT: Evolutionary rescue following environmental change requires mutations permitting population growth in the new environment. If change is severe enough to prevent most of the population reproducing, rescue becomes reliant on mutations already present. If change is sustained, the fitness effects in both environments, and how they are associated-termed 'environmental pleiotropy'-may determine which alleles are ultimately favoured. A population's demographic history-its size over time-influences the variation present. Although demographic history is known to affect the probability of evolutionary rescue, how it interacts with environmental pleiotropy during severe and sustained environmental change remains unexplored. Here, we demonstrate how these factors interact during antibiotic resistance

SUBMITTER: Gifford DR 

PROVIDER: S-EPMC6180006 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature