Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

ABSTRACT: Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of signals from the environment and integrate that information with the regulation of genes critical for infection. Here we report the transcriptome of the attaching and effacing pathogen Citrobacter rodentium during infection of its natural murine host. Pathogen gene expression in vivo was heavily biased towards the virulence factor repertoire and was found to be co-ordinated uniquely in response to the host. Concordantly, we identified the host-specific induction of a metabolic pathway that overlapped with the regulation of virulence. The essential type 3 secretion system and an associated suite of distinct effectors were found to be modulated co-ordinately through a unique mechanism involving meta

SUBMITTER: Connolly JPR 

PROVIDER: S-EPMC6180029 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature