Power law fitness landscapes and their ability to predict fitness.

ABSTRACT: Whether or not evolution by natural selection is predictable depends on the existence of general patterns shaping the way mutations interact with the genetic background. This interaction, also known as epistasis, has been observed during adaptation (macroscopic epistasis) and in individual mutations (microscopic epistasis). Interestingly, a consistent negative correlation between the fitness effect of beneficial mutations and background fitness (known as diminishing returns epistasis) has been observed across different species and conditions. We tested whether the adaptation pattern of an additional species, Schizosaccharomyces pombe, followed the same trend. We used strains that differed by the presence of large karyotype differences and observed the same pattern of fitness convergence. U

SUBMITTER: Passagem-Santos D 

PROVIDER: S-EPMC6180038 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature