CX₃CR1 differentiates F4/80^low monocytes into pro-inflammatory F4/80^high macrophages in the liver.

ABSTRACT: The expression of chemokine receptor CX₃CR1 is related to migration and signaling in cells of the monocyte-macrophage lineage. The precise roles of CX₃CR1 in the liver have been investigated but not clearly elucidated. Here, we investigated the roles of CX₃CR1 in hepatic macrophages and liver injury. Hepatic and splenic CX₃CR1^lowF4/80^low monocytes and CX₃CR1^lowCD16^- monocytes were differentiated into CX₃CR1^highF4/80^high or CX₃CR1^highCD16⁺ macrophages by co-culture with endothelial cells. Moreover, CX₃CL1 deficiency in human umbilical vein endothelial cells (HUVECs) attenuated the expression of interleukin-1β (IL-1β)

SUBMITTER: Lee YS 

PROVIDER: S-EPMC6180058 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature