Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory.

ABSTRACT: The hippocampus contains one of the few neurogenic niches within the adult brain-the subgranular zone of the dentate gyrus. The functional significance of adult-born neurons in this region has been characterized using context fear conditioning, a Pavlovian paradigm in which animals learn to associate a location with danger. Ablation or silencing of adult-born neurons impairs both acquisition and recall of contextual fear conditioning, suggesting that these neurons contribute importantly to hippocampal memory. Lesion studies indicate that CFC depends on neural activity in both the dorsal and ventral hippocampus, subregions with unique extrahippocampal connectivity and behavioral functions. Because most studies of adult neurogenesis have relied on methods that permanently ablate neurogenesis

SUBMITTER: Huckleberry KA 

PROVIDER: S-EPMC6180107 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature