Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls.

ABSTRACT: Depressed patients frequently exhibit a hyperstable brain arousal regulation. According to the arousal regulation model of affective disorders, the antidepressant effect of therapeutic sleep deprivation could be achieved by counter-acting this dysregulation. We investigated the impact of partial sleep deprivation (PSD) on EEG-vigilance (an indicator of brain arousal regulation) in depressed patients (n = 27) and healthy controls (n = 16). PSD was hypothesized to cause a more prominent destabilisation of brain arousal regulation in depressed patients (reflected by increased occurrence of lower EEG-vigilance stages). Furthermore, it was studied whether responders (n = 17) exhibit a more stable baseline brain arousal regulation and would show a more prominent arousal destabilisation after PSD

SUBMITTER: Sander C 

PROVIDER: S-EPMC6180108 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature