TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABA_A receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.

ABSTRACT: GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS), and other neuropsychiatric disorders. Some evidence suggests that TPA-023, (7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b] pyridazine), a GABA_A α2,3 subtype-selective GABA_A partial agonist and α_1/5 antagonist, and the neurosteroid, pregnenolone sulfate, a GABA_A antagonist, may improve CIAS in pilot clinical trials. The goal of this study was to investigate the effect of TPA-023 in mice after acute or subchronic (sc) treatment with the N-methyl-D-aspartate receptor (NMDAR) antagonist, phencyclidine (PCP), on novel object recognition (NOR

SUBMITTER: Rajagopal L 

PROVIDER: S-EPMC6180114 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature