Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry.

ABSTRACT: Multiple myeloma (MM) is two- to three-fold more common in African Americans (AAs) compared to European Americans (EAs). This striking disparity, one of the highest of any cancer, may be due to underlying genetic predisposition between these groups. There are multiple unique cytogenetic subtypes of MM, and it is likely that the disparity is associated with only certain subtypes. Previous efforts to understand this disparity have relied on self-reported race rather than genetic ancestry, which may result in bias. To mitigate these difficulties, we studied 881 patients with monoclonal gammopathies who had undergone uniform testing to identify primary cytogenetic abnormalities. DNA from bone marrow samples was genotyped on the Precision Medicine Research Array and biogeographical ancestry was

SUBMITTER: Baughn LB 

PROVIDER: S-EPMC6180134 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature