Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection.

ABSTRACT: Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers the recruitment of mast cell progenitors to the lung. This process starts early after infection and leads to the accumulation of mast cells. Previous studies showed that an adaptive immune response was required to trigger the recruitment of mast cell progenitors to the lung in a mouse model of allergic lung inflammation. Therefore, we set out to determine whether an adaptive immune response against the virus is needed to cause the influenza-induced recruitment of mast cell progenitors to the lung. We found that influenza-induced recruitmen

SUBMITTER: Zarnegar B 

PROVIDER: S-EPMC6180200 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature