Complement 7 Is Up-Regulated in Human Early Diabetic Kidney Disease.

ABSTRACT: There is a temporal window from the time diabetes is diagnosed to the appearance of overt kidney disease during which time the disease progresses quietly without detection. Currently, there is no way to detect early diabetic nephropathy (EDN). Herein, we performed an unbiased assessment of gene-expression analysis of postmortem human kidneys to identify candidate genes that may contribute to EDN. We then studied one of the most promising differentially expressed genes in both kidney tissue and blood samples. Differential transcriptome analysis of EDN kidneys and matched nondiabetic controls showed alterations in five canonical pathways, and among them the complement pathway was the most significantly altered. One specific complement pathway gene, complement 7 (C7), was significantly elevat

SUBMITTER: Sircar M 

PROVIDER: S-EPMC6180251 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature