Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.

ABSTRACT: Argonaute 2 bound mature microRNA (Ago2-miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. In this study, we identified four wound inflammation-related Ago2-miRNAs (miR-139-5p, miR-142-3p, miR-142-5p, and miR-223) and show that miR-223 is critical for infection control. miR-223^Y/- mice exhibited delayed sterile healing with prolonged neutrophil activation and interleukin-6 expression, and markedly improved repair of Staphylococcus aureus-infected wounds. We also showed that the expression of miR-223 was regulated by CCAAT/enhancer binding protein alpha in human neutrophils after exposure to S. aureus peptides. Treatment with m

SUBMITTER: de Kerckhove M 

PROVIDER: S-EPMC6180296 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature