Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism.

ABSTRACT: Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder that is associated with genetic risk factors. Most human disease-associated single-nucleotide polymorphisms (SNPs) are not located in genes but rather are in regulatory regions that control gene expression. The function of regulatory regions is determined through epigenetic mechanisms. Parallels between the cellular basis of development and the formation of long-term memory have long been recognized, particularly the role of epigenetic mechanisms in both processes. We analyzed how learning alters chromatin accessibility in the mouse hippocampus using a new high-throughput sequencing bioinformatics strategy we call DEScan (differential enrichment scan). DEScan, which enabled the analysis of data from epigenomic experi

SUBMITTER: Koberstein JN 

PROVIDER: S-EPMC6180319 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature