Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.

ABSTRACT:

Background

The cellular effects of androgen are transduced through the androgen receptor, which controls the expression of genes that regulate biosynthetic processes, cell growth, and metabolism. Androgen signaling also impacts DNA damage signaling through mechanisms involving gene expression and transcription-associated DNA damaging events. Defining the contributions of androgen signaling to DNA repair is important for understanding androgen receptor function, and it also has translational implications.

Methods

We generated RNA-seq data from multiple prostate cancer lines and used bioinformatic analyses to characterize androgen-regulated gene expression. We compared the results from cell lines with gene expression data from prostate cancer xenografts, and patient samples, t

SUBMITTER: Jividen K 

PROVIDER: S-EPMC6180441 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature