Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children.

ABSTRACT:

Background

Research on acute kidney injury (AKI) has focused on identifying early biomarkers. However, whether AKI could be diagnosed in the absence of the classic signs of clinical AKI and whether the condition of subclinical AKI, identified by damage or functional biomarkers in the absence of oliguria or increased serum creatinine (sCr) levels, is clinically significant remains to be elucidated in critically ill children. The aims of the study were to investigate the associations between urinary cystatin C (uCysC) levels and AKI and mortality and to determine whether uCysC-positive subclinical AKI is associated with adverse outcomes in critically ill neonates and children.

Methods

In this prospective cohort study, uCysC levels were serially measured during the first week a

SUBMITTER: Fang F 

PROVIDER: S-EPMC6180629 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature