Fibroblast growth factor 21 and fructose dynamics in humans.

ABSTRACT:

Objective

Fructose consumption is a risk factor for metabolic disease. We recently demonstrated that fibroblast growth factor 21 (FGF21), a metabolic hormone involved in lipid and glucose metabolism, is acutely stimulated in humans by 75 g oral fructose, with peak levels occurring 2 h after consumption. This study reports on the dose dependency and reproducibility of the FGF21 response to fructose.

Methods

Lean, healthy adults drank either five different doses of fructose dissolved in water, each separated by 2 weeks, or the same dose on three occasions, each separated by 1 week.

Results

Fibroblast growth factor 21 levels peaked at 2 h in a dose-dependent manner. No significant increase in FGF21 was seen after consumption of 10 g fructose, while robust increases were

SUBMITTER: Migdal A 

PROVIDER: S-EPMC6180711 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature