Differences in Cpg Island Distribution Between Subgenotypes of the Hepatitis B Virus Genotype.

ABSTRACT: BACKGROUND Hepatitis B virus (HBV) genotypes show genomic variations, resulting in different CpG islands in each HBV genotypes or subgenotype. This study aimed to establish reference sequences for each HBV subgenotype of A-H genotypes and to analyze the characteristics of the CpG islands. MATERIAL AND METHODS There were 3,037 retrieved whole-genome sequences of HBV genotypes A-H from GenBank, 28 subgenotype reference sequences were established for these genotypes. CpG islands of the subgenotype reference sequences were analyzed, and 939 strains were selected from the 3,037 genomic sequences. Differences in CpG islands between subgenotypes were compared using the chi-squared and non-parametric tests. RESULTS Of the 28 subgenotype reference sequences established, 11 subgenotype reference seq

SUBMITTER: Chen L 

PROVIDER: S-EPMC6180904 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature