A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease.

ABSTRACT:

Background

GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis.

Method

Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases.

Results

A total of 26 articles

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6180987 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature