MnO nanoparticles with potential application in magnetic resonance imaging and drug delivery for myocardial infarction.

ABSTRACT:

Background

Myocardial infarction (MI) is a leading cause of death worldwide. Therefore, nanoparticles that applied for specific diagnosis of the infarcted area and/or local myocardial delivery of therapeutic agents, are highly desired.

Materials and methods

Herein, we developed the MnO-based nanoparticles, with magnetic resonance (MR) and near-infrared fluorescence imaging modalities as an MR imaging contrast agent and potential drug vehicle for the detection and treatment of MI. The chemophysical characteristics, targeting ability toward infarcted myocardium, biodistribution, and biocompatibility of the MnO-based nanoparticles were studied.

Results

It was found that the MnO-based dual-modal nanoparticles possess high r ₁ relaxivity and induced no no

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC6181115 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature