PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils.

ABSTRACT: Targeted drug carriers are attractive for the delivery of therapeutics directly to the site of a disease, reducing systemic side effects and enhancing the efficacy of therapeutic molecules. However, the use of particulate carriers for drug delivery comes with its own set of challenges and barriers. Among these, a great deal of research effort has focused on protecting carriers from clearance by phagocytes via altering carrier surface chemistry, mostly with the use of polyethylene glycol (PEG) chain coatings. However, few papers have explored the effects of PEGylation on uptake by freshly-obtained primary human phagocytes in physiological conditions. In this work, we investigate the effect of PEGylation on particle uptake by primary human neutrophils in vitro and compare these effects to se

SUBMITTER: Kelley WJ 

PROVIDER: S-EPMC6181144 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature