Once-Daily Cyclosporine-A-MiDROPS for Treatment of Dry Eye Disease.

ABSTRACT:

Purpose

To determine if a Microemulsion Drug Ocular Penetration System (MiDROPS) formulation of cyclosporine A (CsA) delivers more drug and is more efficacious for treatment of dry eye disease (DED) than the current clinical formulation.

Methods

Tissue distribution of CsA was quantified by liquid chromatography with tandem mass spectrometry (LC-MS/MS). To assess tolerability, CsA-MiDROPS (0.1%) was applied to the eyes of rabbits twice per day for 14 days and assessed using ophthalmoscopic examinations. Mice were exposed to desiccating stress for 10 days and received daily topical instillation of the vehicle or test agent. Cornea staining was done to quantify corneal permeability. Histologic quantification of goblet cell (GC) density and CD4⁺ T-cell infiltration in

SUBMITTER: Coursey TG 

PROVIDER: S-EPMC6181191 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature