Optimising sampling regimes and data collection to inform surveillance for trachoma control.

ABSTRACT: It is estimated that 190 million individuals are at risk of blindness from trachoma, and that control by mass drug administration (MDA) is reducing this risk in many populations. Programs are monitored using prevalence of follicular trachoma disease (TF) in children. However, as programs progress to low prevalence there are challenges interpreting this indirect measure of infection. PCR and sero-surveillance are being considered as complementary tools to monitor low-level transmission, but there are questions on how they can be most effectively used. We use a previously-published, mathematical model to explore the dynamic relationship between TF and PCR throughout a control program and a sero-catalytic model to evaluate the utility of two cross-sectional sero-surveys for estimating sero-co

SUBMITTER: Pinsent A 

PROVIDER: S-EPMC6181273 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature