Cardiovascular and Renal Outcomes With Canagliflozin According to Baseline Kidney Function.

ABSTRACT:

Background

Canagliflozin is approved for glucose lowering in type 2 diabetes and confers cardiovascular and renal benefits. We sought to assess whether it had benefits in people with chronic kidney disease, including those with an estimated glomerular filtration rate (eGFR) between 30 and 45 mL/min/1.73 m² in whom the drug is not currently approved for use.

Methods

The CANVAS Program randomized 10 142 participants with type 2 diabetes and eGFR >30 mL/min/1.73 m² to canagliflozin or placebo. The primary outcome was a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke, with other cardiovascular, renal, and safety outcomes. This secondary analysis describes outcomes in participants with and without chronic kidney disease,

SUBMITTER: Neuen BL 

PROVIDER: S-EPMC6181277 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature