Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.

ABSTRACT:

Background

Pulmonary hypertension (PH) due to left heart failure (HF) is the most common form of PH. However, treatment is unclear because there are conflicting results about safety and efficacy of PH-targeted therapies.

Objectives

To assess the effects of PH-targeted therapy on exercise capacity in HF patients.

Methods

MEDLINE, EMBASE and the Cochrane Library were searched from January 1990 to July 2017 for randomized controlled trials comparing PH-targeted therapies to conventional therapy in HF. The primary outcome was to assess the effects on exercise capacity. Secondary outcomes included mortality, hospitalisation, NT-proBNP levels, echocardiographic and hemodynamics parameters and discontinuation rate.

Results

22 studies were included (n = 5448), includin

SUBMITTER: Guay CA 

PROVIDER: S-EPMC6181322 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature