Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis.

ABSTRACT:

Objective

Identification of a biomarker for disease activity in eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss) remains an unmet need. This study examined the value of serum periostin, a marker of type 2 inflammation, as a measure of disease activity in patients with EGPA.

Methods

Participants enrolled in a multicenter, prospective cohort of patients with EGPA were included in this study if they had disease activity (defined as Birmingham Vasculitis Activity Score [BVAS] > 0) during follow-up. Serum levels of periostin were measured at flare visit as well as two pre- and two post-flare visits, if available. The outcome of disease activity was assessed either with BVAS or Physician Global Assessment (PGA). Mixed-effect models were used to examine the assoc

SUBMITTER: Rhee RL 

PROVIDER: S-EPMC6181402 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature