Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design.

ABSTRACT: Vaccination is an effective method to protect against infectious diseases. An important consideration in any vaccine formulation is the inoculum dose, i.e., amount of antigen or live attenuated pathogen that is used. Higher levels generally lead to better stimulation of the immune response but might cause more severe side effects and allow for less population coverage in the presence of vaccine shortages. Determining the optimal amount of inoculum dose is an important component of rational vaccine design. A combination of mathematical models with experimental data can help determine the impact of the inoculum dose. We illustrate the concept of using data and models to inform inoculum dose determination for vaccines, wby fitting a mathematical model to data from influenza A virus (IAV) infe

SUBMITTER: Handel A 

PROVIDER: S-EPMC6181424 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature