Systematic review and meta-analysis of the effect of probiotic supplementation on functional constipation in children.

ABSTRACT:

Background

To evaluate the effect of probiotic supplementation on functional constipation in children.

Methods

We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative risk or weighted mean difference was calculated to evaluate the treatment effect of probiotics using random-effects model.

Results

We included 4 trials reporting data on 382 children with functional constipation. Overall, there were no significant differences in treatment success (P = .697), spontaneous bowel movements per week (P = .571), fecal soiling episodes per week (P = .642), straining at defecation (P = .408), use of lactulose (P = .238), use of laxa

SUBMITTER: Jin L 

PROVIDER: S-EPMC6181519 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature