Association between NR3C1 rs41423247 polymorphism and depression: A PRISMA-compliant meta-analysis.

ABSTRACT:

Background

A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is closely related to the occurrence of depression. The glucocorticoid receptor, also known as the nuclear receptor subfamily 3, group C, member 1 (NR3C1), provides negative feedback to the HPA axis by binding to glucocorticoids. Some studies have demonstrated an association between the NR3C1 rs41423247 polymorphism and depression, but results from other studies have been controversial.

Method

In this study, the association between the NR3C1 rs41423247 polymorphism and depression was evaluated by a meta-analysis using the RevMan 5.3 software, and the Stata 10.0 software was used for sensitivity analysis and publication bias test. According to the inclusion criteria, related studies in databases were re

SUBMITTER: Peng Q 

PROVIDER: S-EPMC6181539 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature