Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS.

ABSTRACT: The increase in cAMP levels in endothelial cells triggers cellular signaling to alter vascular permeability. It is generally considered that cAMP signaling stabilizes the endothelial barrier function and reduces permeability. However, previous studies have only examined the permeability shortly after cAMP elevation and thus have only investigated acute responses. Because cAMP is a key regulator of gene expression, elevated cAMP may have a delayed but profound impact on the endothelial permeability by altering the expression of the genes that are vital for the vessel wall stability. The small guanosine triphosphate hydrolase Ras-related protein (R-Ras) stabilizes VE-cadherin clustering and enhances endothelial barrier function, thereby stabilizing the integrity of blood vessel wall. Here we

SUBMITTER: Perrot CY 

PROVIDER: S-EPMC6181640 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature