Association of Hospitalization, Critical Illness, and Infection with Brain Structure in Older Adults.

ABSTRACT:

Objectives

To examine the association between hospitalization, critical illness, and infection occurring during middle- and late-life and structural brain abnormalities in older adults.

Design

Prospective cohort study.

Setting

Atherosclerosis Risk in Communities (ARIC) Study.

Participants

A community sample of adults who were 44 to 66 years of age at study baseline.

Measurements

Active surveillance of local hospitals and annual participant contact were used to gather hospitalization information (including International Classification of Diseases, Ninth Revision, codes) on all participants over a 24-year surveillance period. Subsequently, a subset of participants underwent 3-Tesla brain magnetic resonance imaging (MRI) to quantify total and regional brain

SUBMITTER: Walker KA 

PROVIDER: S-EPMC6181772 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature